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Dementia Warning Under-65s Brain Health Risk

Dementia Warning:  Under-65s Brain Health Risk

Dementia Warning Under-65s Brain Health Risk


In a concerning revelation, medical experts have identified factors that pose a significant threat to brain health, potentially increasing the risk of early-onset dementia in individuals under the age of 65. This discovery serves as a critical warning for proactive measures and heightened awareness in the fight against cognitive decline.I understand that you are concerned about the risk factors for dementia in people under 65 years of age. According to a recent study published in JAMA Neurology, there are key risk factors that could increase a person’s chances of developing dementia early 12

While age, family history, race, and ethnicity undeniably influence one’s dementia risk, lifestyle choices, such as alcohol consumption and mental health, emerge as pivotal factors shaping cognitive well-being. It’s a dynamic interplay where personal choices intertwine with inherent factors, painting a nuanced picture of dementia risk.

Recent findings published in JAMA Neurology highlight  crucial risk factors associated with an elevated likelihood of developing dementia symptoms before the age of 65. However, the research also offers a silver lining—raising awareness of these key factors may potentially mitigate the risk, providing an avenue for proactive intervention and improved cognitive well-being.

Understanding the Risk Landscape

Dementia Warning Under-65s Brain Health Risk


A recent medical study has shed light on a comprehensive list of factors that could potentially jeopardize brain health and escalate the vulnerability to dementia in individuals under 65. The identification of these factors emphasizes the need for a nuanced understanding of the various elements influencing cognitive well-being.

The  Factors Posing a Threat

    1. Lower Formal Education:

      • Limited formal education has been linked to a higher risk of early-onset dementia. Continuous cognitive stimulation through education may play a protective role against cognitive decline.
    2. Lower Socioeconomic Status:

      • Individuals with lower socioeconomic status may experience reduced access to healthcare, mental stimulation, and healthy lifestyle resources, contributing to an increased risk of early-onset dementia.
    3. Two Copies of the APOE4 Gene:

      • APOE4 is a gene associated with Alzheimer’s disease. Having two copies of the APOE4 gene increases the susceptibility to developing dementia, particularly at a younger age.
    4. Alcohol Use Disorder:

      • Excessive and prolonged alcohol use, leading to alcohol use disorder, is a recognized risk factor. Chronic alcohol misuse can have detrimental effects on brain structure and function.
    5. Social Isolation:

      • Lack of social engagement and isolation can lead to cognitive decline. Social interactions stimulate the brain and contribute to overall mental well-being.
    6. Vitamin D Deficiency:

      • Inadequate levels of vitamin D have been linked to cognitive impairment. Vitamin D is essential for various neurological functions, and its deficiency may contribute to the risk of dementia.
    7. High C-reactive Protein Levels:

      • Elevated C-reactive protein levels indicate inflammation in the body. Chronic inflammation is associated with an increased risk of cognitive decline and dementia.
    8. Lower Handgrip Strength:

      • Lower handgrip strength is considered a physical marker that may reflect overall frailty. Physical frailty has been associated with an increased risk of cognitive decline.
    9. No Alcohol Use:

      • Surprisingly, abstaining from alcohol has also been associated with an increased risk of dementia. The relationship between alcohol and dementia is complex, and moderate alcohol consumption may have potential protective effects.
    10. Hearing Impairment:

      • Hearing impairment is recognized as a sensory factor influencing cognitive health. It can lead to social isolation and impact cognitive stimulation, contributing to the risk of dementia.
    11. Diabetes:Dementia Warning Under-65s Brain Health Risk

      • Diabetes, particularly when unmanaged, is known to have adverse effects on vascular health and is a recognized risk factor for cognitive decline and dementia.
    12. Heart Disease:

      • Conditions like heart disease may impact blood flow to the brain, potentially contributing to the development of dementia symptoms.
    13. Depression:

      • Depression is a well-established risk factor for dementia. Chronic depressive symptoms can lead to changes in the brain that may contribute to cognitive decline.
    14. Orthostatic Hypotension:

      • Orthostatic hypotension, characterized by a sudden drop in blood pressure upon standing, may result in reduced blood flow to the brain, potentially impacting cognitive function.

 Implications for Public Health

Dementia Warning

The identification of these  factors underscores the importance of a holistic approach to brain health. Public health initiatives, increased awareness, and personalized interventions can play a pivotal role in mitigating these risks and promoting cognitive well-being.


With dementia rates on the rise, understanding and addressing these risk factors become paramount. Initiatives focused on preventive healthcare, lifestyle modifications, and mental health support can collectively contribute to a future where early-onset dementia is better understood and effectively managed.

In the face of the potential challenges posed by dementia, it’s clear that proactive measures can significantly impact cognitive health. While complete prevention might be elusive, understanding and addressing risk factors empower individuals to take control of their well-being.

From recognizing the intricate connections between lifestyle and dementia risk to adopting strategies that promote cognitive resilience, the journey towards a healthier future is within reach. By embracing awareness, making informed choices, and partnering with supportive resources like TYE Medical, you can chart a course towards a more resilient and vibrant cognitive future.


Q1: Can addressing these factors reduce the risk of early-onset dementia? 

Yes, proactive measures such as managing cardiovascular health, adopting a healthy lifestyle, and addressing mental health concerns can contribute to reducing the risk of early-onset dementia.

Q2: How can individuals under 65 incorporate preventive measures into their daily lives?

Adopting a balanced diet, staying physically active, prioritizing mental health, and seeking prompt medical attention for underlying conditions are key steps individuals can take.

Q3: Is there ongoing research to further understand and address early-onset dementia risks? 

Yes, ongoing research aims to deepen our understanding of these factors and develop targeted interventions to mitigate the risk of early-onset dementia in diverse populations.

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